PERMISSIVE HYPERCAPNIA EBNEO Review on Permissive Hypercapnia and Increased Risk for Neurodevelopmental Sequelae
CONFERENCE VIDEO SERIES: BARBARA SCHMIDT Watch as Barbara Schmidt discusses the strengths, weaknesses, and results of recent oxygen saturation trials in extremely preterm infants.
CONFERENCE VIDEO SERIES: SARA DEMAURO Watch as Sara DeMauro discusses epidemiology, outcomes, and evidence-based analysis of timing of neonatal tracheostomy.
Bronchopulmonary Dysplasia Permissive hypercapnia has been proposed as a way to limit ventilator-induced lung injury and prevent the development of BPD in preterm neonates. This randomized controlled trial assessed whether targeting higher PaCO2 in the first 14 days of life would prevent BPD in ELBW infants. Interim analysis revealed no benefit to permissive hypercapnia, and this study was stopped early (~20% of planned recruitment). Further study is needed to define the role of permissive hypercapnia in the NICU.
NORMOTHERMIA Maintaining normothermia in preterm infants after birth remains a challenge. Meyer and colleagues have demonstrated that the use of heated humidified gas during preterm infants stabilization improves temperature on admission to NICU. However, firm recommendations for clinical practice cannot be given at this time based on the limited evidence currently available.