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Preterm Neuroimaging and School-Age Cognitive Outcomes

PRETERM NEUROIMAGING The prediction of neurodevelopmental outcomes among infants born at <28 weeks' gestational age is challenging and inexact. This prospective study assessed the usefulness of near-term neuroimaging in predicting the development of poor neurodevelopmental outcomes among these infants and found that at school age, there was a consistent association between near-term adverse cranial ultrasound findings (35-42 weeks' gestational age) and cognitive impairment compared to early CUS (4-14 days of age) or MRI. Thus, near-term cranial ultrasound may be a useful predictor of neurodevelopmental outcome in infants born at <28 weeks' gestational age.

Growing identification of genetic etiologies for neonatal-onset epilepsies: lessons from the Neonatal Seizure Registry

EPILEPSY Determining the etiology of neonatal seizures can be complicated in the absence of an acute insult. This prospective cohort study followed neonates diagnosed with seizures, and compared those who had been diagnosed with epileptic encephalopathy to those who had acute symptomatic seizures, and found that genetic etiology was identifiable in 59% of neonates with epilepsy. Although this study requires additional follow-up, genetic testing may be useful in determining etiology and directing therapies in neonates with epilepsy.