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Growing identification of genetic etiologies for neonatal-onset epilepsies: lessons from the Neonatal Seizure Registry

EPILEPSY Determining the etiology of neonatal seizures can be complicated in the absence of an acute insult. This prospective cohort study followed neonates diagnosed with seizures, and compared those who had been diagnosed with epileptic encephalopathy to those who had acute symptomatic seizures, and found that genetic etiology was identifiable in 59% of neonates with epilepsy. Although this study requires additional follow-up, genetic testing may be useful in determining etiology and directing therapies in neonates with epilepsy.

Does Using a Nasal Barrier Dressing Prevent Nasal Injury in Premature Infants Receiving Nasal Continuous Positive Airway Pressure?

Nasal CPAP Non-invasive ventilation is essential in the NICU, but is commonly associated with nasal injury. This prospective trial assessed the usefulness of nasal barrier dressings in preventing nasal injury in neonates <30 weeks' gestational age receiving NCPAP. Although there were significant limitations to the study, nasal barrier dressings significantly reduced the both the occurrence and degree of nasal injury.

Does tight glycemic control with insulin therapy in the early neonatal period improve long-term outcomes?

HYPERGLYCEMIA Hyperglycemia commonly complicates the clinical course of premature infants, but data regarding the safety and efficacy of insulin therapy are mixed. This randomized controlled trial assessed the effectiveness of blood glucose maintenance with insulin therapy among VLBW infants with hyperglycemia. The study’s two year followup data indicate that “tight” glycemic control with immediate initiation of insulin therapy and targeting lower blood glucose concentrations did not improve neurodevelopmental outcome compared to standard insulin therapy, although height, lean body mass, and fasting blood glucose differed between the two groups. Additional followup is required to determine whether early insulin therapy is appropriate for management of neonatal hyperglycemia.

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We welcome individuals and institutions around the world to sign up for EBNEO membership. Membership allows you to: log in and post comments on all News and Reviews receive our monthly newsletters – curated content from the newly published neonatal clinical research literature helps you stay up-to-date learn about conferences and educational activities before information…

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About

About

The International Society for Evidence-Based Neonatology (EBNEO) is a non-profit organisation that nourishes a vision that all neonatal care should be firmly built on best available evidence. The vision includes as short a passage from research-based knowledge to implementation in neonatal care (translation), thereby improving survival, decreasing morbidities and promoting long-lasting health for newborn infants. Memberships are open for individuals and institutions from all around the world.

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