PDA Indomethacin and Ibuprofen, two effective and commonly-used treatments for hemodynamically significant patent ductus arteriosus (hs-PDA), are associated with adverse clinical events, poor neurodevelopmental outcome, and BPD. This trial assessed the effectiveness of paracetamol as an alternative to indomethacin or ibuprofen in closing a hs-PDA in neonates born at <28 weeks gestation or <1500 grams, and found that paracetamol is equally as effective in inducing PDA closure and was associated with fewer GI bleeding events and renal effects. This EBNEO review comments on the role of CONSORT reporting guidelines in interpreting the results of RCTs.
Early Onset Sepsis Early-onset sepsis (EOS) is a leading cause of neonatal death, but limited tools exist to accurately identify neonates with EOS and prevent those at low risk of EOS from unnecessary antibiotic exposure. This observational study assessed the use of an EOS calculator to modify antibiotic use and EOS workup in neonates > 35 weeks’ gestation at trial centers. The study demonstrated that use of the EOS calculator was associated with reduced evaluation for sepsis and reduced antibiotic use without increases in illness severity. Thus, use of the EOS calculator may be appropriate in the NICU.
We welcome individuals and institutions around the world to sign up for a membership. An institutional membership grants employees to become individual members free of charge. All memberships are valid for one year. Institutions and individuals residing in developing countries, as defined by the UN, get a 50% fee discount. Read more information here on how…
We are very active on Twitter!
Find the latest tweets from and about EBNEO here!
The International Society for Evidence-Based Neonatology (EBNEO) is a non-profit organisation that nourishes a vision that all neonatal care should be firmly built on best available evidence. The vision includes as short a passage from research-based knowledge to implementation in neonatal care (translation), thereby improving survival, decreasing morbidities and promoting long-lasting health for newborn infants. Memberships are open for individuals and institutions from all around the world.