Each year, there are thousands of new contributions to the neonatal literature. Few change practice. Which 2021 publication will have the most impact on neonatal care? Review the nominees in the links below and make your selections by voting on Twitter on each date.EBNEO.AOTY21.12.15
In alphabetical order:
Beardsall K, Thomson L, Guy S, et al. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adol. 2021;5(4): 265-273.
Blakely ML, Tyson JE, Lally KP, et al. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation – A Multicenter Randomized Clinical Trial. Annals Surg. 2021;274(4):370-380.
Dargaville PA, Kamlin COF, Orsini F, et al. Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome The OPTIMIST-A Randomized Clinical Trial. JAMA. 2021;326(6):2478-87.
Hunt RW, Liley HG, Wagh D, et al. Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates A Randomized Clinical Trial. JAMA Network Open. 2021;4(12):e2139604.
Thayyil S, Pant S, Montaldo P, et al. Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh. Lancet Global Health. 2021; 9(9):e1273-85
2. Franz AR, Engel C, Bassler D, et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. JAMA. 2020; 324(6): 560-570.
7. Vento G, Ventura ML, Pastorino R., et al. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial. Lancet Resp Med. 2021;9(2):159-166.