Article of the Year

Which Publication Will Have the Most Impact on Neonatal Care?

Help Select the 2021 EBNEO Impact Article of the Year!

Each year, there are thousands of new contributions to the neonatal literature. Few change practice. Which 2021 publication will have the most impact on neonatal care? Review the nominees in the links below and make your selections by voting on Twitter on each date. 


Review the Nominees

In alphabetical order:

Beardsall K, Thomson L, Guy S, et al. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adol. 2021;5(4): 265-273.

Blakely ML, Tyson JE, Lally KP, et al. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation – A Multicenter Randomized Clinical Trial. Annals Surg. 2021;274(4):370-380.

Dargaville PA, Kamlin COF, Orsini F, et al. Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome The OPTIMIST-A Randomized Clinical Trial. JAMA. 2021;326(6):2478-87.

Deprest JA, Nicolaides KH, Benachi A, et al. Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia. NEJM. 2021;385:107-118.

Hunt RW, Liley HG, Wagh D, et al. Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates A Randomized Clinical Trial. JAMA Network Open. 2021;4(12):e2139604.

Kirpalani H, Bell EF, Hintz SR, et al. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. NEJM. 2020; 383:2639-51. 

Thayyil S, Pant S, Montaldo P, et al. Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh. Lancet Global Health. 2021; 9(9):e1273-85

WHO Immediate KMC Study Group.  Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight. 2021; 384: 2028-2038.

Past Results

The 2020 EBNEO Impact Article of the Year



1.        Cummings JJ, Gerday E, Minton S, et al. Aerosolized calfactant for newborns with respiratory distress syndrome: a randomized trial. Pediatrics. 2020;146(5):e20193967

2.        Franz AR, Engel C, Bassler D, et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. JAMA. 2020; 324(6): 560-570.

3.        Juul SE, Comstock BA, Wadhawan R, et al. A randomized trial of erythropoietin for neuroprotection in preterm infants. N Eng J Med. 2020; 382: 233-243. 

4.        Pejovic NJ, Myrnerts Hook S, Byamugisha J, et al. A randomized trial of laryngeal mask airway in neonatal resuscitation. N Eng J Med. 2020; 383: 2138-2147

5.        Sharpe S, Reiner GE, Davis SL, et al. Levetiracetem versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics. 2020;145(6):e20193182.

6.        van Kempen AAMW, Eskes PF, Nuytemans DHGM, et al. Lower versus traditional treatment threshold for neonatal hypoglycemia. N Eng J Med. 2020; 382: 534-544.

7.        Vento G, Ventura ML, Pastorino R., et al. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial. Lancet Resp Med. 2021;9(2):159-166. 

8.        WHO ACTION Trials Collaborators. Antenatal dexamethasone for early preterm birth in low-resource countries. N Eng J Med. 2020; 383: 2514-2525.

The 2019 EBNEO Impact Article of the Year