ANTENATAL CORTICOSTEROIDS Adminstration of antenatal betamethasone is the standard of care for women at risk of preterm delivery; however, whether antenatal bethamethasone reduces the risk of neonatal complications in the late preterm period is unknown. This randomized controlled trial assessed the effectiveness of two doses of antenatal betamethasone in women at risk of late preterm delivery in preventing neonatal respiratory complications. The trial revealed that despite an increase in neonatal hypoglycemia among neonates whose mothers received betamethasone, the treatment effectively prevents neonatal respiratory complications.
Effective ventilatory support is essential to the survival of extremely preterm infants in the NICU; however, much is still unknown regarding avoidance of treatment failure and progression to invasive mechanical ventilation. This randomized trial assessed the effectiveness of high flow nasal cannula versus nasal CPAP among infants >28 weeks’ gestational age with early RDS, and found an increase in treatment failure among infants receiving high flow nasal cannula.